Structure of Coenzyme Q10
Coenzyme Q10 can exist in three oxidation states: the fully reduced
ubiquinol form (CoQH2), the radical semiquinone intermediate (CoQH•),
and the fully oxidized ubiquinone form (CoQ). All of these forms
are redox active, meaning they have the ability to accept or donate
one or more electrons, and play an important metabolic role in the
conversion of one form to another. This continuous and reversible
transfer of electrons is fundamentally critical to the part Coenzyme
Q10 plays in cellular respiration.
While structurally similar, ubiquinone and ubiquinol function very differently in the body in a metabolic sense. Ubiquinol has two additional hydrogen atoms (therefore adding two electrons) that help facilitate the critical transfer of electrons in the mitochondrial electron transport chain which ultimately leads to the production of ATP. The transfer of these electrons also allows for the strong lipid soluble active antioxidant activity of ubiquinol within the plasma and tissues of the body. 90-95% of the CoQ10 found in a healthy, young individual is in this powerful antioxidant form. In fact, ubiquinol is considered the strongest lipid soluble antioxidant known, providing active defense against oxidative stress.*
What may also make this novel form of CoQ10 so much more effective
than most CoQ10 supplements on the market today is its ability to
remain biologically active in the body much longer. In a study on
aged rats, blood concentrations of this new ubiquinol CoQ10 was
3.75-fold greater after eight hours compared to the same amount
of conventional coenzyme Q10.† When compared to conventional (ubiquinone)
CoQ10 supplements, the benefits of WIN CoQ10 are enormously superior.
† Compared to Ubiquinone CoQ10 products, such as Natrol Co-Q10 50mg.